Telephone Support Line 0800 092 7640

Available Monday to Friday 9.00am-5.00pm

Telephone Support Line 0800 092 7640

Available Monday to Friday 9.00am-5.00pm

Telephone Support Line 0800 092 7640

Available Monday to Friday 9.00am-5.00pm

You may wish to fundraise yourself, with family and friends or within your local group. Whatever the idea, be it large or small, we know you will have a great time raising vital funds for Big C.

Did you know we have 12 charity shops across Norfolk including a dedicated Craft Supplies Shop, Furniture Emporium, Bridal and a high-end fashion Boutique? We are always looking for high quality donations.

Volunteer

We are always looking for volunteers including in our Support Centres, shops and at our Fundraising events. Volunteering is a great way to spend some free time, meet new people, and gain experience.

Help us build a new Cancer Support Centre in Norwich. Support our vision to bring greater cancer care nearer to home. Donate now.

Investigating the mechanisms of Fusobacterium nucleatum adaptation to the colorectal cancer tumour microenvironment

Investigating the mechanisms of Fusobacterium nucleatum adaptation to the colorectal cancer tumour microenvironment

2018 Research Grant Award

£46,463 for a 9 month project to start April 2019 at Quadram Institute Bioscience, Norwich Research Park.

Grant Applicants:

Professor Nathalie Juge

Arjan Narbad (co-applicant)

Colorectal cancer (CRC), also known as bowel cancer and colon cancer, is the development of cancer from the colon or rectum (parts of the large intestine). Some risk factors include diet (red and processed meat), obesity, smoking and lack of physical activity. In addition, increasing evidence links the gut microbiota (inhabiting the large intestine) with colorectal cancer.

The bacterium Fusobacterium nucleatum is a common inhabitant of both the oral cavity and the human gut and shown to be increased in the large intestine of patients with colon cancer. F. nucleatum is pathologically and clinically associated with cancer recurrence and patient outcome. Chemotherapy failure is the major cause of recurrence and poor prognosis in colorectal cancer patients. Although the mechanisms leading to F. nucleatum tumour development have been extensively studied, it is not known why F. nucleatum establish itself and proliferates in the local tumour environment in the first place.

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Find out how Big C can support you and your family if you’ve been affected by cancer.

We can help to improve your quality of life, physical health, and mental wellbeing.

Some people take to the skies, run, jump, walk, swim and cycle whilst others make tea, bake cakes or shave heads.

What will you do to make a difference?

Two men from Norfolk who found themselves with cancer and having to travel for treatment, vowed local people would have access to the best treatment and support … and in 1980 the Big C Appeal was formed.